Clinical Decision Technology Laboratory

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Research

Our lab specializes in analysis of temporal data, development of clinical software, and clinical trials. One central question underlies our work: How can new technology enable emergency care that is safer, more effective, and more efficient?

For our recent publications, please see Dr. Reisner's Catalyst page.

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Spinal Cord Injury

After acute spinal cord injury, patients better recover neurological function if blood pressure is maintained within specific ranges. But blood pressure varies through time and frequently falls out of the goal range. Our lab developed the VIGORIS software system which uses artificial intelligence to guide ideal blood pressure management, and we are conducting clinical trials, funded by the Massachusetts Spinal Cord Injury Cure Research Program.

Sepsis

Sepsis is a leading cause of death in US hospitals. Our team developed a sepsis management protocol that significantly reduced antibiotic delays at MGH; addressed a serious risk that is inherent in too many automated sepsis detection algorithms; and developed a novel methodology to interpret sepsis data with improved validity.

Trauma

Trauma is a leading cause of death in young adults. Our team has studied hundreds of trauma patients to characterize patterns of vital-sign abnormalities caused by life-threatening hemorrhage (i.e., bleeding); developed “artificial intelligence” software to automatically identify patients with life-threatening hemorrhage (the software was successfully tested on-board Boston MedFlight); and developed computer simulations to understand how dehydration hurts patients with hemorrhage.

Circulatory Shock

Circulatory shock is a life-threatening condition involving poor blood circulation, often treated in an ICU with powerful medications to maintain safe blood pressure. We have developed techniques to predict when critically ill patients will develop worse blood pressure; and when they require a change in medication dosage.

Our Team

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Andrew Reisner, MD

Director

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Jeremy Pepino

Lead Software Engineer

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Iain Kehoe

Clinical Research Coordinator

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Yang Wang

Lead Software Engineer

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Abigail O'Connell

Research Assistant

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Brett Biebelberg

Research Assistant

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Sarah Girma

Intern

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Stephen Devries, MD

Clinical Advisor

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Chaya Kotturesh

Data scientist

Our Collaborators

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Joshua Goldstein, MD PhD

Co-Director, Center for Neurologic Emergencies, Massachusetts General Hospital; Professor, Harvard Medical School

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Jin-Oh Hahn, PhD

Associate Professor, Department of Mechanical Engineering, University of Maryland

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Thomas Heldt, PhD

Director, Integrative Neuromonitoring and Critical Care Informatics Group; Associate Professor, Department of electrical and biobemical engineering, Massachusetts Institute of Technology

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John Hwabejire, MBBS

Trauma and Acute Care Surgeon & Surgical Intensivist, Massachusetts General Hospital; Assistant Professor of Surgery, Harvard Medical School

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Jarone Lee, MD

Medical Director, Blake 12 Intensive Care Unit, Massachusetts General Hospital; Associate Professor, Harvard Medical School

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